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Anti-GAPDH Monoclonal antibody抗體

英文名稱 Anti-GAPDH Monoclonal antibody

宿主 Mouse

別名 GAPDH

應用 WB IHC IF

稀釋比例 WB 1:3000-8000. IHC 1:100-300. IF 1:100-200.

交叉反應 Human Mouse Rat Monkey Chicken Rabbit Hamster

蛋白分子量 36kDa

Gene ID 2597

保存 Store at -20°C. Avoid freeze / thaw cycles.

儲存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

純化方法 Affinity purification

亞型 IgG1

免疫原 Recombinant protein of human GAPDH

性狀 液體

Public Immunogen Range Recombinant protein of human GAPDH

Subcellular Locations Cytoskeleton Cytosol Nucleus

Swiss Prot P04406

克隆類型 Monoclonal Antibody

背景資料 Glyceraldehyde 3 phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis. As well as functioning as a glycolytic enzyme in cytoplasm, recent evidence suggests that mammalian GAPDH is also involved in a great number of intracellular proceses such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication, and DNA repair. During the last decade a lot of data appeared concerning the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age related neuronal diseases, such as Alzheimer's and Huntington's disease. GAPDH is expressed in all cells. It is constitutively expressed in almost all tissues at high levels. There are however some physiological factors such as hypoxia and diabetes that increase GAPDH expression in certain cell types. GAPDH molecule is composed of four 36kDa subunits.

參考文獻

《β-N-Oxalyl-L-α,β-diaminopropionic acid from Panax notoginseng plays a major role in the treatment of type 2 diabetic nephropathy》 作者:Li Jie,Qiu Pengcheng,Wang Siwang,WuJun sheng,He Qiaoyan,Li Kaifeng,Xu Lu 期刊:biomedicine & pharmacotherapy 影響因子:3.743 PMID:30928803

Anti-GAPDH Monoclonal antibody抗體